Conveniently located to serve the areas of Berkeley, CA

Daxxify featured image

Daxxify is an anti-aging treatment that resolves facial wrinkles and fine lines. It acts as a neuromodulator- a substance that makes slight changes to the muscular functioning of the face. Just like Botox, Dysport, and Xeomin, this injectable targets certain muscles that are responsible for the creation of dynamic wrinkles that accompany facial expressions. By preventing these contractions, the overlying skin relaxes and creates a more youthful look.

Treating these lines also prevents them from becoming static, or permanent lines that stay put when the face is at rest. Daxxify is more durable than other neuromodulators, providing patients with rejuvenating results for up to 6 to 9 months. (1)

If you’re interested in a long-lasting facial rejuvenation solution that will take years off of your appearance, book your consultation today at Nubo Spa located in Berkeley, CA. Our highly trained nurses and estheticians are familiar with many types of facial aging concerns and will guide you toward the procedure that will work best for you. 

To get in contact with our staff today, call (510) 637-9394 or fill out our contact form, and we will get back to you as soon as possible. 

About Daxxify 

As a neuromodulator, Daxxify targets the facial muscle layer, not the skin itself. It shouldn’t be confused with dermal filler treatments like Restylane or Juvéderm which work to provide more hydration and volume to the skin. Instead, Daxxify blocks a chemical substance called acetylcholine, a neurotransmitter within muscle cells that signals contraction and relaxation. 

By strategically applying Daxxify to certain facial muscles, injectors can block acetylcholine and create smoother, subtly more elevated skin in areas of concern. Daxxify’s main ingredient is botulinum toxin, a protein that has been widely studied and used for decades for both cosmetic and medical purposes. When applied to resolve signs of facial aging, it can prevent and treat: 

  • Eleven Lines (Glabellar Lines)
  • Forehead Lines 
  • Neck Banding
  • Crow’s Feet 
  • Brow Descent 

As a more resilient formulation, your injector can apply Daxxify to create a longer-lasting “lip flip”, a minor enhancement to the upper lips that creates a more defined pout. By targeting the orbicularis oris muscle, the skin of the upper lip elevates and reveals more of the lip skin. This allows patients to achieve a subtle, natural-looking accentuation of their lip outline without requiring a dermal filler. 

Medical Uses for Botulinum Toxin 

When used in small amounts, botulinum toxin has successfully treated several muscular disorders and health issues unrelated to aesthetic rejuvenation. Patients can find relief from jaw pain and headaches; it can also treat one of the root causes of masseter hypertrophy, a common but painful problem called temporomandibular joint dysfunction (TMJ). The use of botulinum toxin for the treatment of neck pain is often called “trap tox” since injectors apply it to the trapezius muscle. Other conditions it has been able to treat include chronic migraines, hyperhidrosis, and bladder dysfunctions. (2)  

Daxxify v.s. Botox 

While Botox maintains results for around 3 to 4 months, studies have found that Daxxify can stay in effect for up to 9 months. As a neuromodulator that was initially FDA-approved in 2022, it has the most advanced formula that preserves and stabilizes botulinum toxin. Instead of the blood plasma protein albumin, Daxxify contains a peptide, a smaller version of a protein, called RTP004. (3) 

Candidates for Daxxify

Ideal candidates for Daxxify are individuals with dynamic wrinkles with limited facial volume loss. If dynamic and static wrinkles are the most prevalent signs of aging, Daxxify can produce incredible results. Those who have lost facial fat may benefit more from a dermal filler that can produce more youthful roundness. Prospective patients should not be allergic to lidocaine, the numbing compound in the injections, or the botulinum toxin itself. Finally, candidates should have realistic expectations for their outcome and realize that Daxxify is a temporary solution that will wear off after a few months. 

Personal Consultation

During your consultation at Nubo Spa, you will meet with an injection specialist who has extensive knowledge of Daxxify and facial musculature anatomy. They will evaluate your skin wrinkles and determine if this injectable is right for you. They may explain other treatment options, such as dermal fillers if they think you will benefit most from them instead. You will have the opportunity to ask as many questions as you would like and gain a comprehensive understanding of the steps you need to promote a smooth procedure and outcome. Nubo Spa is dedicated to excellence and will make every effort to ensure you make an informed decision. Call our practice in Berkeley, CA today at (510) 637-9394 or submit your request for a consultation online. We can’t wait to help you attain your aesthetic goals and the confidence of a younger-looking you! 


Since Daxxify could cause some mild and temporary skin discoloration, your injector will require that you refrain from taking medications or supplements with blood-thinning properties, as these can worsen bruising. They will review your current medication list to ensure there aren’t any that could interfere with your Daxxify treatment. Before your appointment, you should arrive with a freshly cleaned face that is makeup-free and free of any skincare products.

Procedure Steps 

Daxxify is considered a “lunchtime” procedure because of how quick and easy it is. The skilled injectors at Nubo Spa understand how the elevator and depressor muscles of the face function, allowing them to target the correct ones to produce the best outcomes. Depressor muscles move downward when they contract, so administering Daxxify to these muscles will allow them to expand and relax. Conversely, elevator muscles will retract downward since they normally function by elevating certain areas of the face. After your injector cleanses your face, they will ask you to make various facial expressions so they will be able to mark out the exact locations of each muscle. This will allow them to carefully place Daxxify where it is needed and avoid adjacent areas. The procedure is comfortable due to the presence of lidocaine in Daxxify and the use of extremely thin needles. 

For the treatment of “crow’s feet”, your injector will identify and inject the orbicularis oculi muscles, and for the elimination of frown lines between the eyebrows, they may inject the glabellar complex. Forehead lines require fewer units (the dosage measurement) of Daxxify since over-injection can make the frontalis muscle, the forehead muscle, move downward, causing brow descent. To avoid this, your injector will also be sure to administer it superficially. The average procedure takes about 20 minutes, and you will be able to go home or back to work immediately afterward.  

Recovery and Results 

After a Daxxify session, you can go back to sedentary work, but you should avoid doing anything strenuous for at least 4 hours. You may have a mild headache and/or slight sensitivity at the injection sites, but this will completely subside within 1 to 2 days. You should be mindful of keeping your head elevated, allowing the Daxxify to settle in without migrating to other muscles. Unwanted migration can result in a slight downward skin pull that can make you look older. However, Nubo Spa injectors are knowledgeable on the proper dosage, depth of administration, and locations to promote the quality results you’re looking for. 

Although you will notice immediate changes, the full effects won’t be apparent until a few days have passed. You will then get to enjoy more youthful, healthier-looking skin without displaying the wrinkles that give away your age. At some point after your first session with Daxxify, you should consult a Nubo Spa esthetician or nurse about proper skin care that will support more rigid, elastic skin to combat further signs of aging. Daxxify can prevent the formation of static wrinkles, but other treatments can augment your results and restore your skin health as a whole. 

Cost of Daxxify in Berkeley, CA 

The cost of Daxxify injections will depend on the number of units your injector administers, the condition or cosmetic issue you wish to address, and your personalized treatment plan going forward. At the time of your consultation, your injector will give you an idea of the total costs associated with your treatment. To read more about our various other anti-aging solutions, consider reading through Nubo Spa’s blog. 

If the resiliency of Daxxify is appealing to you, give us a call at our location in Berkeley, CA at (510) 637-9394, or visit our online form to schedule your consultation at your earliest convenience.  


  1. Salame N, Eber AE, Dover J. DaxibotulinumtoxinA-lanm (DaxxifyTM): A Comprehensive Overview. Skin Therapy Letter. 2023;28(4):1-3. https://pubmed.ncbi.nlm.nih.gov/37440610/ 
  2. Padda IS, Tadi P. Botulinum Toxin. PubMed. Published 2022. https://www.ncbi.nlm.nih.gov/books/NBK557387/
  3. Solish N, Carruthers J, Kaufman J, Rubio RG, Gross TM, Gallagher CJ. Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A. Drugs. 2021;81(18):2091-2101. doi:https://doi.org/10.1007/s40265-021-01631-w